Environmental Sanitation Engineering ›› 2025, Vol. 33 ›› Issue (5): 97-105.doi: 10.19841/j.cnki.hjwsgc.2025.05.014

Previous Articles     Next Articles

Research Progress on Non-carcinogenic Health Risk Assessment of PFAS Mixtures by US EPA

SONG Jiyuan, HOU Songmei, CHEN Ziqiang, BAI Yang, SUN Shujing, JIANG Yahui   

  1. 1. Shenyang Research Institute of Chemical Industry; 2. Shenyang SYRICI Testing Co. Ltd.; 3. Liaoning Provincial Ecological Environment Service Center; 4. Liaoning Provincial Ecological Environment Testing Center
  • Online:2025-10-27 Published:2025-10-27

PDF (PC)

17

PDF (Mobile)

0

Abstract: PFAS (Per- and Polyfluoroalkyl Substances) are ubiquitous compounds of growing concern due to widespread human exposure and their potential adverse health effects. The latest research progress of the non-carcinogenic health risk assessment methods of PFAS mixtures by the United States Environmental Protection Agency (US EPA) were reviewed in this article, focusing on the research progress of mixture benchmark dose (M-BMD) method. The M-BMD method can more accurately describe the relationship between the exposure dose and health effects of PFAS mixtures. According to the dose-response data of different health effects of the mixture components, the most representative effect endpoint can be selected. M-BMD can also be used in combination with other risk assessment methods to form a more comprehensive assessment system and improve the accuracy and reliability of the non-carcinogenic health risk assessment results of PFAS mixtures. In addition, by comparing with the hazard index (HI) method and the relative potency factor (RPF) method, the advantages and disadvantages of the M-BMD method in the health risk assessment of PFAS mixtures were explained, and suggestions for future research directions were proposed for the shortcomings, in order to provide a more scientific theoretical basis for PFAS health risk assessment.

Key words: PFAS, mixture, health risk, M-BMD, environmental media

[1] ZHANG Shuang, LI Jingwei, FU Xiaoli, HOU Xiangshan, LIU Yanhui, WEN Chuanqi, WANG Xujiang, WANG Ziliang, WANG Wenlong, XIE Ying, WANG Sen. Study on the Effect of Functional Admixtures on Stabilized Sandy Soil with Solid Waste-based Sulfur-aluminum-iron Cementitious Materials [J]. Environmental Sanitation Engineering, 2025, 33(1): 15-22.
[2] ZHANG Yingying, LIU Xiaoji, YU Wu, FENG Quanwu, ZHANG Quan, YE Jiang, LI Ye. Analysis of the Inhibition Mechanism and Effect of the Air-cooled Wall on the Coking of Imported Grate Furnace [J]. Environmental Sanitation Engineering, 2025, 33(1): 93-97.
[3] LIU Yanjun, TANG Qiange, WANG Sheng, LI Zhenkun, WANG Jianbing. Release Characteristics and Health Risks of Bioaerosol from Initial Degradation of Campus Food Waste [J]. Environmental Sanitation Engineering, 2024, 32(1): 57-67.
[4] JIANG Weiwei, YANG Hong, YIN Jianxiang. Odor Pollution Characterization and Health Risk Assessment of An Animal Innocuous Treatment Plant [J]. Environmental Sanitation Engineering, 2024, 32(1): 68-78,86.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Environmental Sanitation Engineering, 2022, 30(4): 89 -95 .
[2] YE Jian, WANG Ren, ZHANG Ming ZHU Yongjun, SHEN Yu, YAN Zhenguo, XIAO Qiang, XU Zhongjian, CHEN Lun, YU Hong, WANG Yafei, WANG Shoukang, LIN Xiaoqing, HUANG Qunxing. Research on Intelligent Control and System Development for Industrial Solid Waste Incineration[J]. Environmental Sanitation Engineering, 2025, 33(5): 1 -10 .
[3] SHANG Yu, YU Wu, LI Yujun, ZHOU Kang, LI Qinghai, WANG Shaona. Research on Prediction of Waste Incinerators Operational Parameter Based on Time Series Neural Network Model[J]. Environmental Sanitation Engineering, 2025, 33(5): 11 -17 .
[4] ZHANG Xiaoxing, YE Lu, SHI Zhili, WANG Luochun. Enhanced Performance Study of Zero-valent Iron on Methane Production from Anaerobic Digestion of Kitchen Waste Pressing Liquor[J]. Environmental Sanitation Engineering, 2025, 33(5): 18 -26 .
[5] CHEN Ximei. Study on the Effect of Feed Loading Adjustment on Anaerobic Fermentation Acidification and Recovery of Kitchen Waste[J]. Environmental Sanitation Engineering, 2025, 33(5): 27 -34 .
[6] LIU Xin, CHEN Minjun, LIU Pingshan, CHEN Meichun, WANG Jieping, WANG Zhiming, LIU Bo. Research and Application of the Juice of Cenchrus fungigraminus to Enrich Microorganism for Degradation of Kitchen Waste[J]. Environmental Sanitation Engineering, 2025, 33(5): 35 -41 .
[7] LIU Xinyan, ZHANG Xu, LU Huijie, HU Changxia, MA Jiaxing. Evaluation of Uncertainty in the Determination of Organic Matter Content in Kitchen Waste Compost Products by Using Potassium Dichromate Volumetric Method[J]. Environmental Sanitation Engineering, 2025, 33(5): 42 -48 .
[8] HUANG Xingzhu, HU Pingyu, RONG Yibang, YUAN Weifang, BAI Caipeng, LAN Zhicong, CHEN Hua. Research Progress of Slagging and Its Control Technology in Municipal Solid Waste Incinerator[J]. Environmental Sanitation Engineering, 2025, 33(5): 49 -56,63 .
[9] GONG Shen, CHEN Hui, ZHAI Lixin, HONG Guang, ZHANG Mengyu. Research on the Impact of Waste Classification on the Operation Status of a Certain Incineration Plant[J]. Environmental Sanitation Engineering, 2025, 33(5): 57 -63 .
[10] DUAN Feifei, ZHU Chuanqiang, HAN Hao. Practice and Analysis of SCR Catalyst Offline High-temperature Regeneration Engineering in Municipal Solid Waste Incineration Project[J]. Environmental Sanitation Engineering, 2025, 33(5): 64 -69 .
Copyright © Environmental Sanitation Engineering
Address: 107#, Weidi Road, Tianjin, P.R.C.　 　 Postcode: 300201
Telephone: 022-28365069 　 Fax: 022-28365080 E-mail: csglwyjs10@tj.gov.cn
Supported by:Beijing Magtech