Abstract: The application effect of 5M1E management in epidemic prevention and control and standardized operation of medical waste disposal center during the epidemic period of COVID-19 pneumonia was discussed. Using the 5M1E management plan， combined with the characteristics of the medical waste disposal center， the management measures from the six aspects of manpower， machine， material， environment， methods and measurement were taken. And a number of epidemic prevention and control suggestions for medical waste disposal centers were put forward.The results showed that outbreak of the COVID-19 pneumonia to the present（January 1， 2020—March 25， 2022）， the medical waste and epidematic-related waste within the service scope of the medical waste disposal center shall be collected and disposed of as much as possible. And there have been no suspected or confirmed cases of COVID-19 related to the collection， transportation and disposal of medical waste. The disposal center operates stably and regulated， with zero complaints. It was effective and feasible to implement the 5M1E management plan during the new crown pneumonia epidemic， which was worth learning and promoting.

Key words: medical waste, COVID-19 epidemic, prevention and control strategy, 5M1E management method