Abstract: With the continuous advancement of waste classification system， on the one hand， the transfer system and facilities used for mixed waste will be overcapacity， and some transfer stations will even be idle. On the other hand， it is necessary to build special transfer facilities for the various source separation（classification） waste， including bulky waste， garden waste and other emerging waste. How to turn new problems and challenges into new opportunities， and realize the reconstruction of the new waste transfer system through redistribution and reuse of the existed resources were new issues that governments and competent authorities at all levels must solve. The location of bulky waste collection and distribution facilities was taken as a breakthrough， committed to construct a part of the domestic waste transfer stations with excess capacity into bulky waste collection and distribution facilities. By analyzing the influencing factors which affect the location of bulky waste collection and distribution facilities， the analytic hierarchy process and expert scoring methods were used to determine the weights of economic， environmental and social targets. The multi-objective site selection model of bulk waste collection and distribution facilities with optimal comprehensive benefits was established， and the multi-objective was transformed into a single objective model. Haikou City was taken as an example， and Tabu search algorithm was adopted to solve the problem. The site selection results and its influencing factors were analyzed， which concluded that the factor with greater impact on the comprehensive target value of the system was the distance of bulky waste transportation.