美国EPA关于PFAS混合物非致癌健康风险评估研究进展

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美国EPA关于PFAS混合物非致癌健康风险评估研究进展

1 沈阳化工研究院；2 沈阳沈化院测试技术有限公司；3 辽宁省生态环境事务服务中心；4 辽宁省生态环境检测中心

Research progress on non-carcinogenic health risk assessment of PFAS mixtures by US EPA

1 Shenyang Research Institute of Chemical Industry；2 Shenyang Shenyang Research Institute of Chemical Industry Testing Technology Co., Ltd.3 Liaoning Provincial Ecological Environment Service Center；4 Liaoning Provincial Ecological Environment Testing Center

摘要/Abstract

摘要：

~~PFAS~~（全氟和多氟烷基物质）（per- and polyfluoroalkyl substances，PFAS）作为一种在日常生活中频繁接触且受到高度关注的化合物，其对人体潜在的负面影响引起了广泛关注。本文旨在综述美国环保署(US EPA) PFAS混合物非致癌健康风险评估方法的最新研究进展，重点介绍了混合物基准剂量法（（mixture benchmark dose，M-BMD））的研究进展， M-BMD方法能够更精确地描述PFAS混合物暴露剂量与健康效应之间的关系，根据混合物组分不同健康效应的剂量反应数据，选择最具代表性的效应终点，M-BMD也可以与其他风险评估方法结合使用，形成更全面的评估体系，提高PFAS混合物非致癌健康风险评估结果的准确性和可靠性。此外，通过与危害指数法（hazard index，HI）、相对效能因子法（relative potency factor，RPF）对比，阐述了M-BMD方法在PFAS混合物健康风险评估优势与不足，并针对不足之处提出未来研究方向建议，以期为PFAS的健康风险评估提供更加科学的理论依据。

关键词: PFAS')">

PFAS, 混合物, 健康风险, M-BMD, 环境介质

Abstract:

PFAS (per- and polyfluoroalkyl substances) are compounds that are frequently exposed to and highly concerned in daily life, and their potential negative impact on the human body has attracted widespread attention. This article aims to review the latest research progress of the non-carcinogenic health risk assessment methods of PFAS mixtures by the United States Environmental Protection Agency (US EPA), focusing on the research progress of the mixture benchmark dose method (M-BMD). The M-BMD method can more accurately describe the relationship between the exposure dose and health effects of PFAS mixtures. According to the dose-response data of different health effects of the mixture components, the most representative effect endpoint is selected. M-BMD can also be used in combination with other risk assessment methods to form a more comprehensive assessment system and improve the accuracy and reliability of the non-carcinogenic health risk assessment results of PFAS mixtures. In addition, by comparing with the hazard index method (HI) and the relative potency factor~~relative effectiveness factor~~ method (RPF), the advantages and disadvantages of the M-BMD method in the health risk assessment of PFAS mixtures are explained, and suggestions for future research directions are proposed for the shortcomings, in order to provide a more scientific theoretical basis for the health risk assessment of PFAS.

Key words: PFAS')">

PFAS, mixture, health risk, M-BMD, environmental media

宋纪元, 侯松嵋, 陈自强, 白杨, 孙书晶, 蒋亚辉.

美国EPA关于PFAS混合物非致癌健康风险评估研究进展 [J]. 环境卫生工程, 0, (): 0-.

Song Jiyuan, Hou Songmei, Chen Ziqiang, Bai Yang, Sun Shujing, Jiang Yahui.

Research progress on non-carcinogenic health risk assessment of PFAS mixtures by US EPA [J]. Environmental Sanitation Engineering, 0, (): 0-.

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